Macrocyclic Complexes: Potent Molecules against Drug Resistant Microbes

The metal ion chemistry of macrocyclic ligands has now become a major subdivision of inorganic chemistry and is a growing area of research in inorganic and bioinorganic chemistry. The field of macrocylic chemistry of metals is developing very fast because of its applications and importance in the area of coordination chemistry. Macrocyclic ligands and their transition metal complexes have received considerable attention because of their pharmacological properties. Metal ion plays important role in biology which has lead to the development of huge number of metal complexes with diverse therapeutic. Macrocyclic metal complexes are best prepared by ‘metal template condensation reactions’. Metals can play an important role in modifying the pharmacological properties of known drugs as chelation causes drastic change in biological properties of ligands. The application of inorganic chemistry to medicine is a rapidly developing field. The novel therapeutic and diagnostic metal complexes are now having an impact on medical practice. Advances in biocoordination chemistry are crucial for improving the design of compounds to reduce toxic side effects and understand their mechanisms of action.The potential for further development of metal-based drugs and treatments as an antimicrobial agent is enormous and also of great importance with the evolution of drug-resistant bacteria and threats from a range of viral diseases. This review tries to summarize the effectiveness of Macrocyclic complexes as antimicrobial agent against microbes.